1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-
JNK Inhibitor IX
CAS: 312917-14-9
Molecular Formula: C20H16N2OS
1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- - Names and Identifiers
1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- - Physico-chemical Properties
| Molecular Formula | C20H16N2OS |
| Molar Mass | 332.42 |
| Density | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 88-90oC |
| Boling Point | 486.8±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming) |
| Appearance | Tan solid |
| Color | Off-white |
| pKa | 11.95±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | JNK inhibitor IX significantly reduces caspase-3 activity in human skin fibroblasts by inhibiting JNK activity JNK inhibitor IX-mediated inhibition of JNK by preventing complete dephosphorylation of c-ABL on serine residues, significantly increased apoptotic death after imatinib mesylate (IM) treatment. |
1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.008 ml | 15.041 ml | 30.082 ml |
| 5 mM | 0.602 ml | 3.008 ml | 6.016 ml |
| 10 mM | 0.301 ml | 1.504 ml | 3.008 ml |
| 5 mM | 0.06 ml | 0.301 ml | 0.602 ml |
Last Update：2024-01-02 23:10:35
1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- - Reference Information
| biological activity | JNK inhibitor IX (TCS JNK 5a) is a highly selective inhibitor of JNK, its pIC50 for JNK2 and JNK3 were 6.5 and 6.7, respectively. |
| Target | Value |
| JNK3 | 6.7(pIC50) |
| JNK2 | 6.5(pIC50) |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: JNK Inhibitor IX Visit Supplier Webpage Request for quotationCAS: 312917-14-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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